What We Do
Tumor Clonal Evolution
We investigate how tumor clones evolve over time and space, revealing the dynamic processes of mutation accumulation, subclonal expansion, and selective pressures during tumorigenesis.
Tumor Microenvironment
We study the cellular and molecular composition of the tumor microenvironment, focusing on immune and stromal interactions that shape tumor progression and therapeutic response.
Tumor-Associated Neutrophils (TANs)
We explore the heterogeneity and function of TANs across different cancer contexts, aiming to understand their dual roles and identify therapeutic strategies targeting neutrophil plasticity.
Extrachromosomal Circular DNA (ecDNA)
We investigate oncogene-bearing ecDNA and its role in promoting tumor aggressiveness, therapy resistance, and genomic instability through advanced sequencing and computational methods.
Our Research
Online Resources
Explore scRNA-seq data of liver cancer.
Explore scRNA-seq, ST, CODEX and IHC data of Acral Melanoma.
Explore scRNA-seq and Visium HD data of nasopharyngeal carcinoma.